Article
Association of HSD3B1 and HSD3B2 gene polymorphisms with essential hypertension, aldosterone level, and left ventricular structure.
European journal of endocrinology - 1 Oct 2010
Shimodaira Masanori, Nakayama Tomohiro, Sato Naoyuki, Aoi Noriko, Sato Mikano, Izumi Yoichi, Soma Masayoshi, Matsumoto Koichi
Abstract excerpt
BACKGROUND: HSD3B1 and HSD3B2 are crucial enzymes for the synthesis of hormonal steroids, including aldosterone. Therefore, HSD3B gene variations could possibly influence blood pressure (BP) by affecting the aldosterone level. METHODS: We performed a haplotype- and diplotype-based case-control study to investigate the association between the HSD3B gene variations and essential hypertension (EH), aldosterone...
Topics
- Adult
- Aldosterone
- Case-Control Studies
- Echocardiography
- Female
- Genotype
- Haplotypes
- Humans
- Hypertension
- Hypertrophy, Left Ventricular
- Male