Article
Common Polymorphisms at the CYP17A1 Locus Associate With Steroid Phenotype: Support for Blood Pressure Genome-Wide Association Study Signals at This Locus.
Hypertension (Dallas, Tex. : 1979) - 1 Apr 2016
Diver Louise A, MacKenzie Scott M, Fraser Robert, McManus Frances, Freel E Marie, Alvarez-Madrazo Samantha, McClure John D, Friel Elaine C, Hanley Neil A, Dominiczak Anna F, Caulfield Mark J, Munroe Patricia B, Connell John M, Davies Eleanor
Abstract excerpt
Genome-wide association studies implicate the CYP17A1 gene in human blood pressure regulation although the causative polymorphisms are as yet unknown. We sought to identify common polymorphisms likely to explain this association. We sequenced the CYP17A1 locus in 60 normotensive individuals and observed 24 previously identified single-nucleotide polymorphisms with minor allele frequency >0.05. From these, we...
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