Article

Istaroxime treatment ameliorates calcium dysregulation in a zebrafish model for Phospholamban R14del cardiomyopathy

2020-11-26

Abstract excerpt

The heterozygous phospholamban ( PLN ) p.Arg14del (R14del) mutation is found in patients with dilated or arrhythmogenic cardiomyopathy. The PLN R14del mutation triggers cardiac contractile dysfunction and arrhythmogenesis by affecting intracellular Ca 2+ dynamics. Little is known about the physiological processes preceding PLN R14del induced cardiomyopathy, which is characterized by sub-epicardial accumulation o...

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Literature Corpus work: ff258b6e-e7af-56f5-b7ef-f77b65448984
DOI: 10.1101/2020.11.25.397422

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