Article
Independent pathways downstream of the Wnd/DLK MAPKKK regulate synaptic structure, axonal transport, and injury signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 31 Jul 2013
Klinedinst Susan, Wang Xin, Xiong Xin, Haenfler Jill M, Collins Catherine A
Abstract excerpt
Mitogen-activated protein (MAP) kinase signaling cascades orchestrate diverse cellular activities with common molecular players. To achieve specific cellular outcomes in response to specific signals, scaffolding proteins play an important role. Here we investigate the role of the scaffolding protein JNK interacting protein-1 (JIP1) in neuronal signaling by a conserved axonal MAP kinase kinase kinase, known as...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- Animals, Genetically Modified
- Axonal Transport
- Drosophila
- Drosophila Proteins
- Horseradish Peroxidase
- Larva
- MAP Kinase Kinase Kinases
- MAP Kinase Signaling System