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Article

Loss of the spectraplakin short stop activates the DLK injury response pathway in Drosophila.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 Nov 2013

Valakh Vera, Walker Lauren J, Skeath James B, DiAntonio Aaron

Abstract excerpt

The MAPKKK dual leucine zipper-containing kinase (DLK, Wallenda in Drosophila) is an evolutionarily conserved component of the axonal injury response pathway. After nerve injury, DLK promotes degeneration of distal axons and regeneration of proximal axons. This dual role in coordinating degeneration and regeneration suggests that DLK may be a sensor of axon injury, and so understanding how DLK is activated is...

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Source

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Identifiers

PMID: 24198375
DOI: 10.1523/JNEUROSCI.2196-13.2013
PMCID: PMC3818558

Genes

TCP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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