Article
Metabolite traits and genetic risk provide complementary information for the prediction of future type 2 diabetes.
Diabetes care - 1 Sept 2014
Walford Geoffrey A, Porneala Bianca C, Dauriz Marco, Vassy Jason L, Cheng Susan, Rhee Eugene P, Wang Thomas J, Meigs James B, Gerszten Robert E, Florez Jose C
Abstract excerpt
OBJECTIVE: A genetic risk score (GRS) comprised of single nucleotide polymorphisms (SNPs) and metabolite biomarkers have each been shown, separately, to predict incident type 2 diabetes. We tested whether genetic and metabolite markers provide complementary information for type 2 diabetes prediction and, together, improve the accuracy of prediction models containing clinical traits. RESEARCH DESIGN AND METHODS:...
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