Article
Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study.
BMJ (Clinical research ed.) - 14 Jan 2010
Talmud Philippa J, Hingorani Aroon D, Cooper Jackie A, Marmot Michael G, Brunner Eric J, Kumari Meena, Kivimäki Mika, Humphries Steve E
Abstract excerpt
OBJECTIVES: To assess the performance of a panel of common single nucleotide polymorphisms (genotypes) associated with type 2 diabetes in distinguishing incident cases of future type 2 diabetes (discrimination), and to examine the effect of adding genetic information to previously validated non-genetic (phenotype based) models developed to estimate the absolute risk of type 2 diabetes. DESIGN: Workplace based...
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