Article
Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry.
Annals of internal medicine - 21 Apr 2009
Cornelis Marilyn C, Qi Lu, Zhang Cuilin, Kraft Peter, Manson JoAnn, Cai Tianxi, Hunter David J, Hu Frank B
Abstract excerpt
BACKGROUND: Genome-wide association studies have identified novel type 2 diabetes loci, each of which has a modest impact on risk. OBJECTIVE: To examine the joint effects of several type 2 diabetes risk variants and their combination with conventional risk factors on type 2 diabetes risk in 2 prospective cohorts. DESIGN: Nested case-control study. SETTING: United States. PARTICIPANTS: 2809 patients with type 2...
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