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Article

Off-target effect of doublecortin family shRNA on neuronal migration associated with endogenous microRNA dysregulation.

Neuron - 18 Jun 2014

Baek Seung Tae, Kerjan Geraldine, Bielas Stephanie L, Lee Ji Eun, Fenstermaker Ali G, Novarino Gaia, Gleeson Joseph G

Abstract excerpt

Acute gene inactivation using short hairpin RNA (shRNA, knockdown) in developing brain is a powerful technique to study genetic function; however, discrepancies between knockdown and knockout murine phenotypes have left unanswered questions. For example, doublecortin (Dcx) knockdown but not knock...

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Identifiers

PMID: 24945770
DOI: 10.1016/j.neuron.2014.04.036
PMCID: PMC4086250

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24945770-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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