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Article

Heterotopia Formation in Rat but Not Mouse Neocortex after RNA Interference Knockdown of DCX

16 Nov 2005

Abstract excerpt

Subcortical band heterotopia (SBH) or double cortex is associated with significant impairments in neocortical function including mental retardation and epilepsy. Mutant alleles of DCX in humans typically cause SBH in females and lissencephaly in males, whereas Dcx null mutations in mice neither disrupt neocortical neuronal migration nor cause SBH formation. In utero RNA interference (RNAi) of Dcx in rats, in...

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PMID: 16292002
DOI: 10.1093/cercor/bhj074

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