Article
Efficient in vivo electroporation of the postnatal rodent forebrain.
PloS one - 2 Apr 2008
Boutin Camille, Diestel Simone, Desoeuvre Angélique, Tiveron Marie-Catherine, Cremer Harold
Abstract excerpt
Functional gene analysis in vivo represents still a major challenge in biomedical research. Here we present a new method for the efficient introduction of nucleic acids into the postnatal mouse forebrain. We show that intraventricular injection of DNA followed by electroporation induces strong expression of transgenes in radial glia, neuronal precursors and neurons of the olfactory system. We present two...
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