Article
Alternative transcripts of Dclk1 and Dclk2 and their expression in doublecortin knockout mice.
Developmental neuroscience - 1 Jan 2008
Tuy Françoise Phan Dinh, Saillour Yoann, Kappeler Caroline, Chelly Jamel, Francis Fiona
Abstract excerpt
The doublecortin (DCX) gene, mutated in X-linked human lissencephaly, has 2 close paralogs, doublecortin-like kinase 1 and 2 (Dclk1 and 2). In this study we attempted to better understand the dramatic differences between human and mouse DCX/Dcx-deficient phenotypes, focusing on the Dclk genes which are likely to compensate for Dcx function in the mouse. Using sequence database screens, Northern blot analyses and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.