Article
Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration.
Proceedings of the National Academy of Sciences of the United States of America - 8 Apr 2008
Cuellar Trinna L, Davis Tigwa H, Nelson Peter T, Loeb Gabriel B, Harfe Brian D, Ullian Erik, McManus Michael T
Abstract excerpt
MicroRNAs (miRNAs) are small noncoding RNAs that can act to repress target mRNAs by suppressing translation and/or reducing mRNA stability. Although it is clear that miRNAs and Dicer, an RNase III enzyme that is central to the production of mature miRNAs, have a role in the early development of neurons, their roles in the postmitotic neuron in vivo are largely unknown. To determine the roles of Dicer in neurons,...
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