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Article

Differential coupling of KLF10 to Sin3-HDAC and PCAF regulates the inducibility of the FOXP3 gene.

American journal of physiology. Regulatory, integrative and comparative physiology - 15 Sept 2014

Xiong Yuning, Svingen Phyllis A, Sarmento Olga O, Smyrk Thomas C, Dave Maneesh, Khanna Sahil, Lomberk Gwen A, Urrutia Raul A, Faubion William A

Abstract excerpt

Inducible gene expression, which requires chromatin remodeling on gene promoters, underlies the epigenetically inherited differentiation program of most immune cells. However, chromatin-mediated mechanisms that underlie these events in T regulatory cells remain to be fully characterized. Here, we report that inducibility of FOXP3, a key transcription factor for the development of T regulatory cells, depends upon...

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Identifiers

PMID: 24944246
DOI: 10.1152/ajpregu.00085.2014
PMCID: PMC4166759

Genes

KLF10
FOXP3

Provenance

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