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Article

An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes.

Immunity - 25 May 2012

Darce Jaime, Rudra Dipayan, Li Li, Nishio Junko, Cipolletta Daniela, Rudensky Alexander Y, Mathis Diane, Benoist Christophe

Abstract excerpt

Maintenance of lymphoid homeostasis in a number of immunological and inflammatory contexts is served by a variety of regulatory T (Treg) cell subtypes and depends on interaction of the transcription factor FoxP3 with specific transcriptional cofactors. We report that a commonly used insertional mutant of FoxP3 (GFP-Foxp3) modified its molecular interactions, blocking HIF-1α but increasing IRF4 interactions. The...

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Identifiers

PMID: 22579475
DOI: 10.1016/j.immuni.2012.04.007
PMCID: PMC3386606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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