Article
Integration of biological data by kernels on graph nodes allows prediction of new genes involved in mitotic chromosome condensation.
Molecular biology of the cell - 15 Aug 2014
Hériché Jean-Karim, Lees Jon G, Morilla Ian, Walter Thomas, Petrova Boryana, Roberti M Julia, Hossain M Julius, Adler Priit, Fernández José M, Krallinger Martin, Haering Christian H, Vilo Jaak, Valencia Alfonso, Ranea Juan A, Orengo Christine, Ellenberg Jan
Abstract excerpt
The advent of genome-wide RNA interference (RNAi)-based screens puts us in the position to identify genes for all functions human cells carry out. However, for many functions, assay complexity and cost make genome-scale knockdown experiments impossible. Methods to predict genes required for cell functions are therefore needed to focus RNAi screens from the whole genome on the most likely candidates. Although...
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