Article
[Genotype-phenotype correlation in ADPKD: a possible role for NGAL?].
Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia - 1 Jan 2000
Virzì Grazia Maria, Gastaldon Fiorella, Corradi Valentina, de Cal Massimo, Cruz Dinna N, Clementi Maurizio, Ronco Claudio
Abstract excerpt
BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic cause of chronic kidney disease (CKD) in adults. It is associated with both inter- and intra- familial variability, which can be explained by genetic heterogeneity, modifier genes and a genetic background. NGAL, a 25-kDa protein released from tubular cells after harmful stimuli, is a new biomarker. Recent studies suggest a...
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