[Current opinions about the etiology and pathogenesis of autosomal dominant polycystic kidney disease (ADPKD). I. Selected genetic aspects and mechanisms of cyst formation].

Abstract excerpt

The aim of this study is to present in the chronological order evolution of opinions about the etiopathogenesis of Autosomal Dominant Polycystic Kidney Disease (ADPKD), with the special regard to the newest genetic investigations. Prevalence of this disease is estimated at 1:1000, and patients with ADPKD compose up to 10% patients, who need renal replacement therapy. Since 1957, when inheritance was defined by...

Topics

• Chromosomes, Human, Pair 16
• Chromosomes, Human, Pair 4
• Genetic Linkage
• Humans
• Mutation
• Polycystic Kidney Diseases