Article
Use of the Urine-to-Plasma Urea Ratio to Predict ADPKD Progression.
Clinical journal of the American Society of Nephrology : CJASN - 8 Feb 2021
Heida Judith E, Gansevoort Ron T, Messchendorp A Lianne, Meijer Esther, Casteleijn Niek F, Boertien Wendy E, Zittema Debbie
Abstract excerpt
BACKGROUND AND OBJECTIVES: Predicting disease progression in patients with autosomal dominant polycystic kidney disease (ADPKD) poses a challenge, especially in early-stage disease when kidney function is not yet affected. Ongoing growth of cysts causes maximal urine-concentrating capacity to decrease from early on. We therefore hypothesized that the urine-to-plasma urea ratio, as a reflection of the...
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