Article
[Progression of autosomic dominant polycystic kidney disease. Influence of endothelial NO synthase (ecNOS) and renin angiotensin system gene polymorphisms].
Medicina - 1 Jan 2004
Azurmendi Pablo, Fraga Adriana, Muchnik Carolina, Dos Ramos Farias Maria, Galan Felicita, Guerra Danisa, O'Flaherty Martin, Arrizurieta Elvira, Martin Rodolfo
Abstract excerpt
Glomerular filtration rate decline (GFRd) is variable in autosomic dominant polycystic kidney disease (ADPKD). In 88 ADPKD patients, GFRd was assessed by 1/S(Cr) and compared with the association to AT1A1166C (AT1R), AGTM235T (angiotensinogen) and ecNOSGlu298Asp (NO endothelial synthase) polymorphisms. Age at S(Cr) values of 2 and 6 mg/dl were assumed as beginning of progressive phase (A2) and end-stage-renal...
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