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Article

The urea decomposition product cyanate promotes endothelial dysfunction.

Kidney international - 1 Nov 2014

El-Gamal Dalia, Rao Shailaja P, Holzer Michael, Hallström Seth, Haybaeck Johannes, Gauster Martin, Wadsack Christian, Kozina Andrijana, Frank Saša, Schicho Rudolf, Schuligoi Rufina, Heinemann Akos, Marsche Gunther

Abstract excerpt

The dramatic cardiovascular mortality of patients with chronic kidney disease is attributable in a significant proportion to endothelial dysfunction. Cyanate, a reactive species in equilibrium with urea, is formed in excess in chronic kidney disease. Cyanate is thought to have a causal role in pr...

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Identifiers

PMID: 24940796
DOI: 10.1038/ki.2014.218
PMCID: PMC4216595

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24940796-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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