High urea and NaCl carbonylate proteins in renal cells in culture and in vivo , and high urea causes 8-oxoguanine lesions in their DNA

Abstract excerpt

UNLABELLED: Urea and NaCl are elevated in the renal inner medulla. We now find that a high concentration of urea or NaCl increases reactive oxygen species (ROS) in mouse renal inner medullary (mIMCD3) cells in culture. Previously, high NaCl, but not high urea, was found to cause DNA double-strand breaks. We now tested whether high urea or NaCl causes oxidative damage to DNA or cellular proteins. We find that high...

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