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Article

Carnosine metabolism in diabetes is altered by reactive metabolites.

Amino acids - 1 Nov 2015

Peters Verena, Lanthaler Barbara, Amberger Albert, Fleming Thomas, Forsberg Elisabete, Hecker Markus, Wagner Andreas H, Yue Wyatt W, Hoffmann Georg F, Nawroth Peter, Zschocke Johannes, Schmitt Claus P

Abstract excerpt

Carnosinase 1 (CN1) contributes to diabetic nephropathy by cleaving histidine-dipeptides which scavenge reactive oxygen and carbonyl species and increase nitric oxide (NO) production. In diabetic mice renal CN1 activity is increased, the regulatory mechanisms are unknown. We therefore analysed the in vitro and in vivo regulation of CN1 activity using recombinant and human CN1, and the db/db mouse model of...

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PMID: 26081982
DOI: 10.1007/s00726-015-2024-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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