Effects of schizophrenia risk variation in the NRG1 gene on NRG1-IV splicing during fetal and early postnatal human neocortical development.

doi:10.1176/appi.ajp.2014.13111518

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Article

Effects of schizophrenia risk variation in the NRG1 gene on NRG1-IV splicing during fetal and early postnatal human neocortical development.

The American journal of psychiatry - 1 Sept 2014

Paterson Clare, Wang Yanhong, Kleinman Joel E, Law Amanda J

Abstract excerpt

OBJECTIVE: Neuregulin 1 (NRG1) is a multifunctional neurotrophin that mediates neurodevelopment and schizophrenia risk. The NRG1 gene undergoes extensive alternative splicing, and association of brain NRG1 type IV isoform expression with the schizophrenia-risk polymorphism rs6994992 is a potential mechanism of risk. Novel splice variants of NRG1-IV (NRG1-IVNV), with predicted unique signaling capabilities, have...

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PMID: 24935406
DOI: 10.1176/appi.ajp.2014.13111518
PMCID: PMC4330971

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NRG1

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