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Article

Specific Regulation of NRG1 Isoform Expression by Neuronal Activity

8 Jun 2011

Abstract excerpt

Neuregulin 1 (NRG1) is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by usage of different promoters and alternative splicing of a single gene. However, little is known about NRG1 isoform composition profile, whether it changes during development, or the underlying mechanisms. We found that each of the six...

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PMID: 21653853
DOI: 10.1523/jneurosci.5317-10.2011

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