Article
Spatial and temporal mapping of de novo mutations in schizophrenia to a fetal prefrontal cortical network.
Cell - 1 Aug 2013
Gulsuner Suleyman, Walsh Tom, Watts Amanda C, Lee Ming K, Thornton Anne M, Casadei Silvia, Rippey Caitlin, Shahin Hashem, Nimgaonkar Vishwajit L, Go Rodney C P, Savage Robert M, Swerdlow Neal R, Gur Raquel E, Braff David L, King Mary-Claire, McClellan Jon M
Abstract excerpt
Genes disrupted in schizophrenia may be revealed by de novo mutations in affected persons from otherwise healthy families. Furthermore, during normal brain development, genes are expressed in patterns specific to developmental stage and neuroanatomical structure. We identified de novo mutations in persons with schizophrenia and then mapped the responsible genes onto transcriptome profiles of normal human brain...
Topics
- Brain
- DNA Mutational Analysis
- Databases, Genetic
- Female
- Gene Regulatory Networks
- Humans
- Male
- Mutation
- Neurogenesis
- Prefrontal Cortex