Temporal, Diagnostic, and Tissue-Specific Regulation of NRG3 Isoform Expression in Human Brain Development and Affective Disorders.

doi:10.1176/appi.ajp.2016.16060721

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Article

Temporal, Diagnostic, and Tissue-Specific Regulation of NRG3 Isoform Expression in Human Brain Development and Affective Disorders.

The American journal of psychiatry - 1 Mar 2017

Paterson Clare, Wang Yanhong, Hyde Thomas M, Weinberger Daniel R, Kleinman Joel E, Law Amanda J

Abstract excerpt

OBJECTIVE: Genes implicated in schizophrenia are enriched in networks differentially regulated during human CNS development. Neuregulin 3 (NRG3), a brain-enriched neurotrophin, undergoes alternative splicing and is implicated in several neurological disorders with developmental origins. Isoform-specific increases in NRG3 are observed in schizophrenia and associated with rs10748842, a NRG3 risk polymorphism,...

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Identifiers

PMID: 27771971
DOI: 10.1176/appi.ajp.2016.16060721
PMCID: PMC5892449

Genes

NRG3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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