WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies.

Abstract excerpt

WWOX was cloned as a putative tumor suppressor gene mapping to chromosomal fragile site FRA16D. Deletions affecting WWOX accompanied by loss of expression are frequent in various epithelial cancers. Translocations and deletions affecting WWOX are also common in multiple myeloma and are associated with worse prognosis. Metanalysis of gene expression datasets demonstrates that low WWOX expression is significantly...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Central Nervous System Diseases
• Share to Evolution, Molecular
• Share to Metabolic Syndrome