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Article

The fragile site WWOX gene and the developing brain.

Experimental biology and medicine (Maywood, N.J.) - 1 Mar 2015

Tabarki Brahim, Al Mutairi Fuad, Al Hashem Amal

Abstract excerpt

WWOX was cloned as a tumor suppressor gene mapping to chromosomal fragile site FRA16D. Loss of WWOX is closely related to tumorigenesis, cancer progression, and therapy resistance. Recent studies demonstrate the growing role of WWOX gene in other human pathologies such as metabolic and nervous system-related conditions. The neurologic phenotype of WWOX mutation includes seizures, ataxia, developmental delay, and...

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Share to Brain
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Oxidoreductases

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Source

Open in PubMed Open full text

Identifiers

PMID: 25416187
DOI: 10.1177/1535370214561952
PMCID: PMC4935222

Genes

WWOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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