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Article

Wwox inactivation enhances mammary tumorigenesis.

Oncogene - 8 Sept 2011

Abdeen S K, Salah Z, Maly B, Smith Y, Tufail R, Abu-Odeh M, Zanesi N, Croce C M, Nawaz Z, Aqeilan R I

Abstract excerpt

Breast cancer is the leading cause of cancer-related death in women worldwide. Expression of the WWOX tumor suppressor is absent or reduced in a large proportion of breast tumors suggesting that loss of WWOX may contribute to breast tumorigenesis. Wwox-deficient mice die by 3-4 weeks of age precluding adult tumor analysis. To evaluate the effect of WWOX-altered expression on mammary tumor formation, the...

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Share to Cell Death
Share to Crosses, Genetic
Share to Mammary Neoplasms, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C3H

Share to Mice, Transgenic

Share to Oxidoreductases

Share to Receptors, Estrogen

Share to WW Domain-Containing Oxidoreductase

Source

Identifiers

PMID: 21499303
DOI: 10.1038/onc.2011.115

Genes

WWOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Semantic proximity does not establish scientific evidence.

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Wwox inactivation enhances mammary tumorigenesis.PMID 21499303Read ↗

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The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism.Semantic proximity Read ↗

WWOX: a fragile tumor suppressor.Semantic proximity Read ↗

WWOX, tumour suppressor and modifier gene, as a regulator of gene expression and apoptosis in ovarian cancerSemantic proximity Read ↗

Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axisSemantic proximity Read ↗

Conditional inactivation of the mouse Wwox tumor suppressor gene recapitulates the null phenotype.Semantic proximity Read ↗

Deletion of the WWOX gene and frequent loss of its protein expression in human osteosarcomaSemantic proximity Read ↗

VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOXSemantic proximity Read ↗

Alteration of WWOX in human cancer: a clinical view.Semantic proximity Read ↗

Pleiotropic Functions of Tumor Suppressor WWOX in Normal and Cancer CellsSemantic proximity Read ↗

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