Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

WWOX, the chromosomal fragile site FRA16D spanning gene: its role in metabolism and contribution to cancer.

Experimental biology and medicine (Maywood, N.J.) - 1 Mar 2015

Richards Robert I, Choo Amanda, Lee Cheng Shoou, Dayan Sonia, O'Keefe Louise

Abstract excerpt

The WWOX gene spans the common chromosomal fragile site FRA16D that is located within a massive (780 kb) intron. The WWOX gene is very long, at 1.1 Mb, which may contribute to the very low abundance of the full-length 1.4 kb mRNA. Alternative splicing also accounts for a variety of aberrant transcripts, most of which are devoid of C-terminal sequences required for WWOX to act as an oxidoreductase. The mouse WWOX...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Fragile Sites
Share to Drosophila Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomic Instability

Share to Neoplasms

Share to Oxidoreductases

Share to Reactive Oxygen Species

Share to Tumor Suppressor Proteins

Share to WW Domain-Containing Oxidoreductase

Source

Open in PubMed Open full text

Identifiers

PMID: 25595186
DOI: 10.1177/1535370214565990
PMCID: PMC4935231

Genes

WWOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

WWOX, the chromosomal fragile site FRA16D spanning gene: its role in metabolism and contribution to cancer.PMID 25595186Read ↗

Molecular Biology of the WWOX Gene That Spans Chromosomal Fragile Site FRA16D.Semantic proximity Read ↗

WWOX: a fragile tumor suppressor.Semantic proximity Read ↗

WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies.Semantic proximity Read ↗

WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer.Semantic proximity Read ↗

Alteration of WWOX in human cancer: a clinical view.Semantic proximity Read ↗

WWOX in biological control and tumorigenesisSemantic proximity Read ↗

Common fragile genes and digestive tract cancers.Semantic proximity Read ↗

FRA16D common chromosomal fragile site oxido-reductase (FOR/WWOX) protects against the effects of ionizing radiation in Drosophila.Semantic proximity Read ↗

The fragile site WWOX gene and the developing brain.Semantic proximity Read ↗

Genetic alterations of the WWOX gene in breast cancer.Semantic proximity Read ↗

Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene.Semantic proximity Read ↗

Molecular Functions of WWOX Potentially Involved in Cancer DevelopmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.