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Article

Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene.

PloS one - 10 Nov 2009

Ludes-Meyers John H, Kil Hyunsuk, Parker-Thornburg Jan, Kusewitt Donna F, Bedford Mark T, Aldaz C Marcelo

Abstract excerpt

WWOX, the gene that spans the second most common human chromosomal fragile site, FRA16D, is inactivated in multiple human cancers and behaves as a suppressor of tumor growth. Since we are interested in understanding WWOX function in both normal and cancer tissues we generated mice harboring a con...

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Source

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Identifiers

PMID: 19936220
DOI: 10.1371/journal.pone.0007775
PMCID: PMC2777388

Genes

WWOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19936220-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene.PMID 19936220Read ↗

Conditional inactivation of the mouse Wwox tumor suppressor gene recapitulates the null phenotype.Semantic proximity Read ↗

Targeted deletion of Wwox reveals a tumor suppressor function.Semantic proximity Read ↗

WWOX: a fragile tumor suppressor.Semantic proximity Read ↗

WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies.Semantic proximity Read ↗

WWOX in biological control and tumorigenesisSemantic proximity Read ↗

The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism.Semantic proximity Read ↗

WWOX, the chromosomal fragile site FRA16D spanning gene: its role in metabolism and contribution to cancer.Semantic proximity Read ↗

The fragile site WWOX gene and the developing brain.Semantic proximity Read ↗

Alteration of WWOX in human cancer: a clinical view.Semantic proximity Read ↗

The supposed tumor suppressor gene WWOX is mutated in an early lethal microcephaly syndrome with epilepsy, growth retardation and retinal degeneration.Semantic proximity Read ↗

Molecular Functions of WWOX Potentially Involved in Cancer DevelopmentSemantic proximity Read ↗

The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation.Semantic proximity Read ↗

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