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Pleiotropic Functions of Tumor Suppressor WWOX in Normal and Cancer Cells

24 Oct 2015

Abstract excerpt

WW domain-containing oxidoreductase (WWOX), originally marked as a likely tumor suppressor gene, has over the years become recognized for its role in a much wider range of cellular activities. Phenotypic effects displayed in animal studies, along with resolution of WWOX's architecture, fold, and binding partners, point to the protein's multifaceted biological functions. Results from a series of complementary...

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PMID: 26499798
DOI: 10.1074/jbc.r115.676346

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