Article
Molecular Insights into the Mechanism of Calmodulin Inhibition of the EAG1 Potassium Channel.
Structure (London, England : 1993) - 4 Oct 2016
Marques-Carvalho Maria João, Oppermann Johannes, Muñoz Eva, Fernandes Andreia S, Gabant Guillaume, Cadene Martine, Heinemann Stefan H, Schönherr Roland, Morais-Cabral João Henrique
Abstract excerpt
The human EAG1 potassium channel belongs to the superfamily of KCNH voltage-gated potassium channels that have roles in cardiac repolarization and neuronal excitability. EAG1 is strongly inhibited by Ca2+/calmodulin (CaM) through a mechanism that is not understood. We determined the binding properties of CaM with each one of three previously identified binding sites (BDN, BDC1, and BDC2), analyzed binding to...
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