Human TERT promoter mutations as a prognostic biomarker in glioma.

doi:10.1007/s00432-021-03536-3

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Article

Human TERT promoter mutations as a prognostic biomarker in glioma.

Journal of cancer research and clinical oncology - 1 Apr 2021

Powter Branka, Jeffreys Sarah A, Sareen Heena, Cooper Adam, Brungs Daniel, Po Joseph, Roberts Tara, Koh Eng-Siew, Scott Kieran F, Sajinovic Mila, Vessey Joey Y, de Souza Paul, Becker Therese M

Abstract excerpt

The TERT promoter (pTERT) mutations, C228T and C250T, play a significant role in malignant transformation by telomerase activation, oncogenesis and immortalisation of cells. C228T and C250T are emerging as important biomarkers in many cancers including glioblastoma multiforme (GBM), where the prevalence of these mutations is as high as 80%. Additionally, the rs2853669 single nucleotide polymorphism (SNP) may...

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Identifiers

PMID: 33547950
DOI: 10.1007/s00432-021-03536-3
PMCID: PMC7954705

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