Article
TERT Promoter Mutation in Adult Glioblastomas: It's Correlation with Other Relevant Molecular Markers.
Neurology India - 1 Jan 2000
Barange Mukesh, Epari Sridhar, Gurav Mamta, Shetty Omshree, Sahay Ayushi, Shetty Prakash, Goda Jayantsastri, Moyiadi Aliasagar, Gupta Tejpal, Jalali Rakesh
Abstract excerpt
BACKGROUND: Telomerase reverse transcriptase promoter (pTERT) mutation is a dominant altered telomere maintenance mechanism in primary glioblastomas (GBMs). OBJECTIVE: The aim of this study was to correlate pTERT mutations with clinico-histological features and other molecular markers (p53 protein-expression, ATRX protein-expression, IDH mutations, EGFR gene amplification and MGMT methylation) in adult GBMs....
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