Article
Promoter methylation and polymorphisms of the MGMT gene in glioblastomas: a population-based study.
Neuroepidemiology - 1 Jan 2009
Zawlik Izabela, Vaccarella Salvatore, Kita Daisuke, Mittelbronn Michel, Franceschi Silvia, Ohgaki Hiroko
Abstract excerpt
O(6)-methylguanine-DNA methyltransferase (MGMT) is a repair enzyme that removes promutagenic O(6)-methylguanine adducts in DNA, to protect cells from acquisition of G:C--> A:T mutations. MGMT promoter methylation and polymorphisms may affect MGMT expression and activity. In the present study, we assessed MGMT promoter methylation and polymorphisms (Leu84Phe, Ile143Val, c.-56C>T) in 371 glioblastomas diagnosed at...
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