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Extracellular matrix control of mammary gland morphogenesis and tumorigenesis: insights from imaging

13 Nov 2008

Abstract excerpt

The extracellular matrix (ECM), once thought to solely provide physical support to a tissue, is a key component of a cell's microenvironment responsible for directing cell fate and maintaining tissue specificity. It stands to reason, then, that changes in the ECM itself or in how signals from the ECM are presented to or interpreted by cells can disrupt tissue organization; the latter is a necessary step for...

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PMID: 19009245
DOI: 10.1007/s00418-008-0537-1

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