Article
Genetic polymorphisms in TLR1, TLR2, TLR4, and TLR10 of Helicobacter pylori-associated gastritis: a prospective cross-sectional study in Thailand.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) - 1 Mar 2018
Tongtawee Taweesak, Bartpho Theeraya, Kaewpitoon Soraya, Kaewpitoon Natthawut, Dechsukhum Chavaboon, Leeanansaksiri Wilairat, Loyd Ryan A, Talabnin Krajang, Matrakool Likit, Panpimanmas Sukij
Abstract excerpt
The toll-like receptors (TLRs) mediate the recognition of Helicobacter pylori and initiate the innate immune response to infection. We hypothesized those genetic polymorphisms in the TLR1, TLR2, TLR4, and TLR10 influence bacterial infection, affecting susceptibility H. pylori to disease outcomes. Genomic DNA was extracted and genotypes of TLR1 (rs4833095), TLR2 (rs3804099 and rs3804100), TLR4 (rs10759932), and...