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Article

The NOD-like receptor signalling pathway in Helicobacter pylori infection and related gastric cancer: a case-control study and gene expression analyses.

PloS one - 1 Jan 2014

Castaño-Rodríguez Natalia, Kaakoush Nadeem O, Goh Khean-Lee, Fock Kwong Ming, Mitchell Hazel M

Abstract excerpt

BACKGROUND: Currently, it is well established that cancer arises in chronically inflamed tissue. A number of NOD-like receptors (NLRs) form inflammasomes, intracellular multiprotein complexes critical for generating mature pro-inflammatory cytokines (IL-1β and IL-18). As chronic inflammation of the gastric mucosa is a consequence of Helicobacter pylori infection, we investigated the role of genetic polymorphisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24901306
DOI: 10.1371/journal.pone.0098899
PMCID: PMC4047072

Genes

NLRP12
CARD8
NLRP3
NLRX1
CASP1
NFKB1
NLRC4
NLRC5
NLRP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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