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Article

Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertension.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2011

Li Min, Riddle Suzette R, Frid Maria G, El Kasmi Karim C, McKinsey Timothy A, Sokol Ronald J, Strassheim Derek, Meyrick Barbara, Yeager Michael E, Flockton Amanda R, McKeon B Alexandre, Lemon Douglas D, Horn Todd R, Anwar Adil, Barajas Carlos, Stenmark Kurt R

Abstract excerpt

Persistent accumulation of monocytes/macrophages in the pulmonary artery adventitial/perivascular areas of animals and humans with pulmonary hypertension has been documented. The cellular mechanisms contributing to chronic inflammatory responses remain unclear. We hypothesized that perivascular inflammation is perpetuated by activated adventitial fibroblasts, which, through sustained production of proinflammatory...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21813768
DOI: 10.4049/jimmunol.1100479
PMCID: PMC3159707

Genes

CCL2
CCL5
CCR7
CXCL12
CXCR4
TIMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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