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The Wnt co-receptor Arrow-LRP5/6 is required for Planar Cell Polarity establishment in <i>Drosophila</i>

2025-09-22

Abstract excerpt

Wnt-signaling, via β-catenin or the planar cell polarity (PCP) branch, is crucial for development, tissue homeostasis, and linked to many diseases. LRP5/6, arrow ( arr ) in Drosophila , is the obligate co-receptor in Wnt/β-catenin signaling, with ligand binding to a Frizzled (Fz) family member and LRP5/6 mediating formation of the signalosome complex with Dishevelled (Dsh/Dvl in mammals) and Axin. Current model...

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Literature Corpus work
175f7e68-a0ce-531f-b69a-0c6b6f9a8582
DOI
10.1101/2025.09.22.677847
Open publication

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The Wnt co-receptor Arrow-LRP5/6 is required for Planar Cell Polarity establishment in <i>Drosophila</i>DOI 10.1101/2025.09.22.677847
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