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Article

RNA clamping by Vasa assembles a piRNA amplifier complex on transposon transcripts.

Cell - 19 Jun 2014

Xiol Jordi, Spinelli Pietro, Laussmann Maike A, Homolka David, Yang Zhaolin, Cora Elisa, Couté Yohann, Conn Simon, Kadlec Jan, Sachidanandam Ravi, Kaksonen Marko, Cusack Stephen, Ephrussi Anne, Pillai Ramesh S

Abstract excerpt

Germline-specific Piwi-interacting RNAs (piRNAs) protect animal genomes against transposons and are essential for fertility. piRNAs targeting active transposons are amplified by the ping-pong cycle, which couples Piwi endonucleolytic slicing of target RNAs to biogenesis of new piRNAs. Here, we describe the identification of a transient Amplifier complex that mediates biogenesis of secondary piRNAs in insect...

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PMID: 24910301
DOI: 10.1016/j.cell.2014.05.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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