Genome near-haploidization in CDC73-wildtype parathyroid tumors.

doi:10.1038/s41598-026-55820-2

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Article

Genome near-haploidization in CDC73-wildtype parathyroid tumors.

Scientific reports - 13 Jun 2026

Jentus Maaia Margo, Cetani Filomena, Snel Marieke, van Haalen Femke M, Ruano Dina, Appelman-Dijkstra Natasha M, Schepers Abbey, Crobach Stijn, Marcocci Claudio, Torregrossa Liborio, Morreau Hans

Abstract excerpt

Parathyroid carcinoma (PC) is most often linked to germline or somatic CDC73 mutations. Previously, we identified three CDC73-wildtype PCs with massive chromosomal losses and genome near-haploidization, with or without endoreduplication/genome doubling - features also seen in rare tumor types such as oncocytic thyroid carcinoma. To assess whether similar alterations occur in other parathyroid neoplasms, we...

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Share to DNA Copy Number Variations
Share to PC gene
Share to Loss of Heterozygosity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42288551
DOI: 10.1038/s41598-026-55820-2
PMCID: PMC13522456

Genes

CDC73
PC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.