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Article

A mutation screening of oncogenes, tumor suppressor gene TP53 and nuclear encoded mitochondrial complex I genes in oncocytic thyroid tumors.

BMC cancer - 21 Mar 2015

Evangelisti Cecilia, de Biase Dario, Kurelac Ivana, Ceccarelli Claudio, Prokisch Holger, Meitinger Thomas, Caria Paola, Vanni Roberta, Romeo Giovanni, Tallini Giovanni, Gasparre Giuseppe, Bonora Elena

Abstract excerpt

BACKGROUND: Thyroid neoplasias with oncocytic features represent a specific phenotype in non-medullary thyroid cancer, reflecting the unique biological phenomenon of mitochondrial hyperplasia in the cytoplasm. Oncocytic thyroid cells are characterized by a prominent eosinophilia (or oxyphilia) caused by mitochondrial abundance. Although disruptive mutations in the mitochondrial DNA (mtDNA) are the most...

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PMID: 25880213
DOI: 10.1186/s12885-015-1122-3
PMCID: PMC4374372

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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