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Article

Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors.

Proceedings of the National Academy of Sciences of the United States of America - 22 May 2007

Gasparre Giuseppe, Porcelli Anna Maria, Bonora Elena, Pennisi Lucia Fiammetta, Toller Matteo, Iommarini Luisa, Ghelli Anna, Moretti Massimo, Betts Christine M, Martinelli Giuseppe Nicola, Ceroni Alberto Rinaldi, Curcio Francesco, Carelli Valerio, Rugolo Michela, Tallini Giovanni, Romeo Giovanni

Abstract excerpt

Oncocytic tumors are a distinctive class of proliferative lesions composed of cells with a striking degree of mitochondrial hyperplasia that are particularly frequent in the thyroid gland. To understand whether specific mitochondrial DNA (mtDNA) mutations are associated with the accumulation of m...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17517629
DOI: 10.1073/pnas.0703056104
PMCID: PMC1885617

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17517629-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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