Article
Genomic and transcriptomic characterization of the mitochondrial-rich oncocytic phenotype on a thyroid carcinoma background.
Mitochondrion - 1 May 2019
Cavadas Bruno, Pereira Joana B, Correia Marcelo, Fernandes Verónica, Eloy Catarina, Sobrinho-Simões Manuel, Soares Paula, Samuels David C, Máximo Valdemar, Pereira Luisa
Abstract excerpt
We conducted the first systematic omics study of the oncocytic phenotype in 488 papillary thyroid carcinomas (PTC) from The Cancer Genome Atlas. Oncocytic phenotype is secondary to PTC, being unrelated to several pathologic scores. The nuclear genome had low impact on this phenotype (except in specific copy number variation), which was mostly driven by the significant accumulation of mitochondrial DNA...
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