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Article

Generation of circulating autoreactive pre-plasma cells fueled by naive B cells in celiac disease

1 Apr 2024

Abstract excerpt

Autoantibodies against the enzyme transglutaminase 2 (TG2) are characteristic of celiac disease (CeD), and TG2-specific immunoglobulin (Ig) A plasma cells are abundant in gut biopsies of patients. Here, we describe the corresponding population of autoreactive B cells in blood. Circulating TG2-specific IgA cells are present in untreated patients on a gluten-containing diet but not in controls. They are clonally...

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PMID: 38578826
DOI: 10.1016/j.celrep.2024.114045

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