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Strong Clonal Relatedness between Serum and Gut IgA despite Different Plasma Cell Origins

1 Sept 2017

Abstract excerpt

Mucosal antigens induce generation of lamina propria plasma cells (PCs) that secrete dimeric immunoglobulin A (IgA) destined for transport across the epithelium. In addition, blood contains monomeric IgA. To study the relationship between mucosal and systemic antibody responses, we took advantage of celiac disease patient samples for isolation of gut PCs as well as serum IgA and IgG reactive with a gluten-derived...

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PMID: 28877470
DOI: 10.1016/j.celrep.2017.08.036

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