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Article

Longevity, clonal relationship, and transcriptional program of celiac disease–specific plasma cells

1 Oct 2020

Abstract excerpt

Disease-specific plasma cells (PCs) reactive with transglutaminase 2 (TG2) or deamidated gluten peptides (DGPs) are abundant in celiac disease (CeD) gut lesions. Their contribution toward CeD pathogenesis is unclear. We assessed expression of markers associated with PC longevity in 15 untreated and 26 treated CeD patients in addition to 13 non-CeD controls and performed RNA sequencing with clonal inference and...

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PMID: 33095260
DOI: 10.1084/jem.20200852

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